Effective Vaccine Ecosystem

Wellcome Trust
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The global vaccine ecosystem does not optimally realise vaccines’ potential to deliver health improvements. With this research effort, Wellcome aims to identify solutions that will improve the vaccine ecosystem, focusing on challenges faced between a vaccine candidate’s transition into Phase 2 clinical development and first country introductions. In alignment with Wellcome’s mission and strategy, this research focused on emerging infectious diseases (EID), diseases affecting low-income countries (LIC) and those with the potential to impact antimicrobial resistance (AMR). Starting from an analysis of the vaccine ecosystem, the research mapped vaccine developers’ decision-making and the challenges faced in their development work. This analysis informed the prioritisation of challenges that have a sizeable impact on developers and public health, and for which solutions could improve the functioning of the vaccine ecosystem.

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